Our highly sensitive Hereditary Breast Cancer Panel analyzes 18 genes, covering all the high penetrance genes included in the NCCN, ASCO, ACOG, and ACMG guidelines, as well as other medium risk genes that have well-established evidence of association with hereditary breast cancer.
Genes Analyzed
| ATM | BARD1 | BRCA1 | BRCA2 | BRIP1 | CDH1 |
| CHEK2 | MRE11A | MUTYH | NBN | NF1 | PALB2 |
| PTEN | RAD50 | RAD5ZC | PAD51D | STK11 | TP53 |
Breast cancer is the most common type of inherited cancer. 1 in every 10 women with breast cancer is predisposed by germline mutations. Mutations in the BRCA1 or BRCA2 genes account for the majority of hereditary breast cancer cases, however, there are other high penetrance genes, such as PTEN and TP53, which have a well-established association with hereditary breast cancer. Individuals with a pathogenic variant in these genes have a significantly increased risk of developing breast cancer.
Lifetime Cancer Risks
Who Should Get Tested?
Certain red flags indicate a higher risk for hereditary breast cancer, which include but are not limited to:
- Early-onset breast cancer.
- Triple-negative breast cancer.
- Bilateral or multiple primary breast cancers.
- Male breast cancer at any age.
- Ashkenazi Jewish descent with breast cancer at any age.
- Ovarian cancer at any age.
- Known BRCA1 or BRCA2 mutation in the family.
- Family history of multiple cancers.
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