Our highly sensitive Hereditary Colorectal Cancer Panel analyzes 17 genes, covering all high penetrance genes as well as other medium risk genes that have well-established evidence of association with hereditary colorectal cancer.
Genes Analyzed
| PAC | AXIN2 | BMPR1A | CDH1 | GALNT12 | GREM1 |
| MLH1 | MSH2 | MSH3 | MUTYH | PMS2 | POLD1 |
| POLE | PTEN | RNF43 | SMAD4 | TP53 |
Colorectal cancer is the third most common cancer in both men and women and the second most common cause of cancer deaths in the United States. About 5% of colorectal cancer is hereditary, caused largely by mutations in mismatch repair genes. Individuals with a pathogenic variant in one of these genes have a significantly increased risk of developing colorectal cancer in their lifetime. The major hereditary colorectal cancer syndromes are Lynch syndrome (previously known as Hereditary NonPolyposis Colorectal Cancer or HNPCC), Familial Adenomatous Polyposis (FAP), Peutz Jeghers syndrome, and Juvenile Polyposis syndrome.
Lifetime Cancer Risks
Who Should Get Tested?
Certain red flags indicate a higher risk for hereditary colorectal cancer, which include but are not limited to:
- Early-onset colorectal cancer.
- Multiple primary cancers, including colorectal cancer.
- Family history of other tumors on the Lynch syndrome spectrum of cancers.
- Tumor testing shows a mismatch repair genes mutation.
- Presence of an abnormally high number (10+) of precancerous colorectal polyps (adenomas).
- Multiple hamartomatous colorectal polyps.
- A clinical or family history that meets the criteria for evaluating specific hereditary colorectal cancer syndromes.
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