Our highly sensitive Hereditary Endometrial Cancer Panel analyzes 13 genes that cover all the high penetrance genes as well as other high and medium risk genes that have well-established evidence of association with hereditary endometrial cancer.
Genes Analyzed
| BRCA1 | BRCA2 | CHEK2 | EPCAM | POLD1 |
| MSH2 | MSH6 | MUTYH | PMS2 | |
| PTEN | STK11 | TP53 | MLH1 |
Uterine cancer is the fourth most common cancer and the sixth most common cause of cancer death among women in the United States. Hereditary endometrial cancer accounts for about 2-5% of all cases, caused largely by mutations in DNA mismatch repair genes. Common inherited syndromes known to increase a woman’s lifetime risk include Lynch syndrome and Cowden syndrome.
Lifetime Cancer Risks
Who Should Get Tested?
Certain red flags indicate a higher risk for hereditary endometrial cancer, which include but are not limited to:
- Endometrial cancer diagnosed under the age of 50.
- Multiple cancers in one person (such as colon cancer and endometrial cancer).
- Tumor testing that indicates mutation in high penetrance genes.
- Multiple relatives diagnosed with endometrial cancer and/or related cancers. (including breast, ovarian, and colon) on the same side of the family and spanning multiple generations.
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