Our highly sensitive Hereditary Melanoma Panel analyzes 7 genes, covering all high penetrance genes as well as other high and medium risk genes that have well-established evidence of association with melanoma.
Genes Analyzed
| BAP1 | BRCA2 | CDK4 | CDKN2A |
| MITF | PTEN | TP53 |
Skin cancer is the most common cancer in the United States and worldwide. Though melanoma accounts for only 1% of skin cancers, it causes a large number of skin cancer-related deaths. About 7–15% of patients with melanoma have a family history of the disease. The most common gene associated with hereditary melanoma is the CDKN2A gene, though several other high and intermediate penetrance melanoma susceptibility genes have been identified. Individuals with a pathogenic variant in one of these genes have a significantly increased risk of developing melanoma.
Lifetime Cancer Risks
Who Should Get Tested?
Certain red flags indicate a higher risk for melanoma, which include but are not limited to:
- Multiple primary melanomas.
- History of melanoma in close relatives on the same side.
- Melanoma along with kidney cancer, pancreatic cancer, or mesothelioma in the same person, or close relatives.
- A family history of a mutation in a gene that predisposes patients to melanoma.
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