Our highly sensitive Hereditary Pancreatic Cancer Panel analyzes 21 genes, covering all high penetrance genes as well as other high and medium risk genes that have well-established evidence of association with hereditary pancreatic cancer.
Genes Analyzed
| PAC | ATM | BMPR1A | BRCA1 | BRAC2 | CDK4 | CDKN4A |
| EPCAM | MEN1 | MLH1 | MSH2 | MSH6 | NF1 | PALB2 |
| PMS2 | SMAD4 | STK11 | TIP53 | TSC1 | TSC2 | VHL |
Approximately 5-10% of pancreatic cancers are hereditary. Several germline mutations are identified in hereditary pancreatic cancers, including BRCA1, BRCA2, PALB2, ATM, CDKN2A, and APC. Individuals with a pathogenic variant in these genes have an increased risk of malignancy compared to the average person. Pancreatic cancer is associated with many hereditary cancer syndromes, such as hereditary pancreatitis and
Lifetime Cancer Risks
Who Should Get Tested?
Certain red flags indicate a higher risk for hereditary pancreatic cancer, which include but are not limited to:
- Pancreatic cancer diagnosed at an early age.
- Multiple cancers in one person (such as pancreatic cancer and breast cancer).
- Close relatives diagnosed with pancreatic cancer and/or related cancers (including breast, colon, and melanoma).
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