Our highly sensitive Hereditary Prostate Cancer Panel analyzes 14 genes, covering all high penetrance genes as well as other medium risk genes that have well-established evidence of association with hereditary prostate cancer.
Genes Analyzed
| ATM | BRCA1 | BRCA2 | CHEK2 | EPCAM | MOXB13 | MLH1 |
| MSH2 | MSH6 | NBN | PALB2 | PMS2 | RAD51D | TP53 |
In the United States, prostate cancer is the second most common cancer among men. About 8% to 12% of patients with advanced prostate cancer have germline mutations. These mutations in high penetrant genes such as BRCA1, BRCA2, ATM, and MLH1 contribute to hereditary prostate cancer, and those who carry them have a significantly increased risk of developing prostate cancer.
Lifetime Cancer Risks
Who should get tested?
Certain red flags indicate a higher risk for hereditary prostate cancer, which include but are not limited to:
- Early-onset prostate cancer.
- Metastatic prostate cancer at any age.
- Multiple primary cancers in one person (e.g. prostate and male breast cancer).
- Family history of breast, ovarian, pancreatic, or prostate cancer.
.png){kind=logo}